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Updated: Mar 29, 2026
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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
Published on: March 2, 2011
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EMAS position statement: Testosterone replacement therapy in the aging male
Christina Dimopoulou1, Iuliana Ceausu2, Herman Depypere3
1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Ring Road -Nea Efkarpia, 564 29 Thessaloniki, Greece.
Maturitas
|November 29, 2015
Summary
Testosterone replacement therapy (TRT) is justified for aging males with late-onset hypogonadism (LOH) and low testosterone. TRT may improve sexual function, obesity, and metabolic issues, but risks require ongoing evaluation.
Area of Science:
- Endocrinology
- Andrology
- Geriatrics
Background:
- Late-onset hypogonadism (LOH) affects aging males, presenting with sexual dysfunction and low testosterone.
- The use of testosterone replacement therapy (TRT) in this population remains a subject of debate.
Purpose of the Study:
- To critically appraise evidence regarding TRT in aging males.
- To outline LOH characteristics, indications, available treatments, monitoring, and risks.
Main Methods:
- Comprehensive literature review.
- Consensus of expert opinion.
Main Results:
- TRT is indicated for LOH when symptoms and low testosterone are confirmed.
- Potential benefits include improvements in obesity, metabolic syndrome, type 2 diabetes, sexual function, and osteoporosis.
- Adverse effects on cardiovascular disease, prostate cancer, and sleep apnea require further investigation.
Conclusions:
- Individualized assessment of comorbidities and risk-benefit analysis are crucial for managing aging men with LOH.
- Scheduled monitoring for adverse events is recommended for patients undergoing TRT.
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