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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Cancer therapy using natural ligands that target estrogen receptor beta

Gangadhara R Sareddy1, Ratna K Vadlamudi2

  • 1Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Chinese Journal of Natural Medicines
|November 29, 2015
PubMed

Insights

Estrogen receptor beta (ERβ) acts as a tumor suppressor by inhibiting cancer cell proliferation. Natural ERβ agonists show promise for cancer therapy by targeting this receptor.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Estrogen receptor beta (ERβ) is a key mediator of 17β-estradiol (E2) actions.
  • ERβ expression is often diminished in various cancers.
  • ERβ signaling involves both genomic and extra-nuclear pathways.

Purpose of the Study:

  • To review the tumor-suppressive functions of ERβ.
  • To explore the clinical potential of natural ERβ agonists in cancer treatment.

Main Methods:

  • Literature review of studies on ERβ signaling and natural ligands.
  • Analysis of ERβ's role in cancer progression and suppression.
  • Evaluation of anti-proliferative effects of ERβ agonists.

Main Results:

  • ERβ exhibits tissue-specific tumor suppressor activity.
  • Natural compounds selectively activating ERβ have been identified.
  • ERβ activation demonstrates anti-proliferative effects in cancer models.

Conclusions:

  • Targeting ERβ with natural ligands is a viable strategy for cancer prevention and therapy.
  • ERβ signaling offers a promising avenue for novel anti-cancer treatments.
Keywords:
ER beta agonistsEstrogen receptorEstrogen receptor betaGenisteinLiquiritigeninS-equolTumor suppressor

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