Related Experiment Video
Updated: Mar 29, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
What Do We Know About the Pathophysiology of Chronic Pain? Implications for Treatment Considerations
1Carolina Pain Associates, PA, 1900 Randolph Road, Suite 1016, Charlotte, NC 28207, USA.
Abstract:
We discuss the complex features of the pathophysiology of chronic pain and the implications for treatment and provide an overview of nociceptive processes, neuropathic pain, cold hyperalgesia, peripheral nerve injury, wind-up pain, central sensitization, and common clinical presentation and diagnostic criteria. Advanced medicine has proven that chronic pain need not involve any structural pathology as pain is a complex biopsychosocial experience. Treatment of the specific mechanisms responsible for pain should be aimed at preventing and or reducing dysfunctional neuro-plasticity resulting from poorly controlled chronic pain. Further study is needed to reduce the probability and of persistent changes that cause chronic pain.
Related Concept Videos
Analgesia and Pain Management
Nociception
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pain
Chronic Pancreatitis II: Collaborative Care
Assessment:
Opioid Analgesics: Synthetic and Semisynthetic Opioids

