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10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.9K
Intravenous Valproate versus Subcutaneous Sumatriptan in Acute Migraine Attack
Fahmida Ghaderibarmi1, Nader Tavakkoli1, Mansoureh Togha2
1Department of Emergency, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Acta Medica Iranica
|November 30, 2015
Summary
Valproate demonstrated faster and more effective acute migraine relief than sumatriptan in a clinical trial. This study suggests valproate as a potentially superior treatment option for migraine headaches.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a debilitating neurological disorder.
- Triptans are a common first-line treatment for acute migraine.
- Valproate is FDA-approved for migraine prophylaxis and shows promise for acute treatment.
Purpose of the Study:
- To compare the efficacy of sumatriptan and valproate for acute migraine treatment.
- To evaluate pain reduction and adverse effects of both medications.
Main Methods:
- A randomized clinical trial involving 37 acute migraine patients.
- Patients received either subcutaneous sumatriptan or intravenous valproate.
- Pain scores and adverse effects were compared between groups.
Main Results:
- Valproate group showed a significantly greater reduction in pain scores compared to sumatriptan.
- Valproate offered a faster onset of action and was more effective.
- No significant recurrence or remarkable side effects were noted with valproate.
Conclusions:
- Valproate is more effective and faster-acting than sumatriptan for acute migraine.
- Valproate presents a promising alternative treatment for acute migraine management.
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