Functional characterization of the tumor suppressor CMTM8 and its association with prognosis in bladder cancer
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Updated: Mar 29, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Shiying Zhang1, Xiaolei Pei2, Hao Hu1
1Department of Urology, Peking University People's Hospital, 11 Xizhimen Street, Xicheng District, Beijing, 100044, China.
Abstract:
Previous research revealed that CMTM8 acts as a tumor suppressor gene in variety cancers. However, the role of CMTM8 in bladder cancer has never been reported. In this study, the expression profile of CMTM8 was examined in bladder cancer tissues and bladder cancer cell lines. The effects of CMTM8 on bladder cancer cell proliferation, apoptosis, migration, and invasion were examined. Bladder tumor tissues from 84 cases were examined for CMTM8 expression by immunohistochemistry. Disease-specific survival was investigated using a Kaplan-Meier analysis, and Cox proportional hazards analysis was assessed. Our results showed that upregulation of CMTM8 in the T24 cell line could suppress T24 cells proliferation, migration and invasion and enhance the sensitivity to Epirubicin. Kaplan-Meier analysis revealed that the expression of CMTM8 was correlated with the survival time of bladder cancer patients. Altogether, our data suggested that CMTM8 is an important tumor suppressor gene in human bladder cancer and qualified as a useful prognostic indicator for patients with bladder cancer.
Insights
This study reveals that CMTM8 functions as a tumor suppressor in bladder cancer. Upregulating CMTM8 inhibits cancer cell growth and improves patient survival, indicating its potential as a prognostic marker.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The gene CMTM8 is recognized as a tumor suppressor in various cancers.
- Its specific role in bladder cancer remains uninvestigated.
- Understanding CMTM8's function is crucial for identifying new therapeutic targets.
Purpose of the Study:
- To investigate the expression profile of CMTM8 in bladder cancer.
- To determine the functional impact of CMTM8 on bladder cancer cell behavior.
- To evaluate CMTM8 as a prognostic indicator for bladder cancer patients.
Main Methods:
- Immunohistochemistry was used to analyze CMTM8 expression in 84 bladder tumor tissues.
- Bladder cancer cell lines were utilized to assess CMTM8's effects on proliferation, apoptosis, migration, and invasion.
- Kaplan-Meier and Cox proportional hazards analyses were performed to correlate CMTM8 expression with patient survival.
Main Results:
- CMTM8 expression was analyzed in bladder cancer tissues and cell lines.
- Upregulation of CMTM8 suppressed proliferation, migration, and invasion in T24 bladder cancer cells.
- CMTM8 expression positively correlated with disease-specific survival in bladder cancer patients.
Conclusions:
- CMTM8 acts as a significant tumor suppressor in human bladder cancer.
- The expression level of CMTM8 is associated with patient prognosis.
- CMTM8 is a potential prognostic biomarker for bladder cancer.
