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DNA replication stress and cancer: cause or cure?

Elaine M Taylor1, Howard D Lindsay1

  • 1Lancaster Medical School, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YG, UK.

Future Oncology (London, England)
|December 1, 2015
PubMed

Insights

Cancer cells rely on DNA replication stress response pathways for proliferation. Targeting these pathways offers a promising therapeutic strategy for various malignancies, potentially halting cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • DNA replication stress is increasingly recognized as a key factor in cancer development and progression.
  • Many cancers depend on replication stress response pathways for survival and proliferation.

Purpose of the Study:

  • To explore the mechanisms linking sustained proliferation to replication stress and genome instability.
  • To discuss the role of oncogene-induced replication stress in human cancers.
  • To consider replication stress as a prognostic indicator and therapeutic target.

Main Methods:

  • Review of existing literature on DNA replication stress and cancer.
  • Analysis of mutation patterns in human cancers.
  • Discussion of oncogene-induced replication stress models.

Main Results:

  • Sustained cellular proliferation can induce replication stress, leading to genome instability.
  • Mutation patterns in human cancers support the oncogene-induced replication stress model.
  • Replication stress response pathways are crucial for cancer cell proliferation.

Conclusions:

  • DNA replication stress is a significant driver of cancer.
  • Targeting replication stress response pathways presents a viable therapeutic avenue for cancer treatment.
  • Replication stress holds potential as both a prognostic biomarker and a therapeutic target in oncology.
Keywords:
ATRCHK1genome instabilityoncogenesreplication stress

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