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MUM-1 expression differentiates AITL with HRS-like cells from cHL
Wenyong Huang1, Jianlan Xie2, Xiao Xu3
1Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China ; Department of Pathology, The First Affiliated Hospital of Jiujiang University Jiujiang, China.
International Journal of Clinical and Experimental Pathology
|December 1, 2015
Summary
MUM1/IRF4 protein aids in distinguishing angioimmunoblastic T-cell lymphoma (AITL) with Hodgkin/Reed-Sternberg (HRS)-like cells from classic Hodgkin lymphoma (cHL). This marker shows high expression in both AITL and cHL, with distinct rosette formation patterns.
Area of Science:
- Hematopathology
- Immunohistochemistry
- Oncology
Background:
- MUM1/IRF4 is a transcription factor expressed in plasma cells, late B cells, and activated T cells.
- It is implicated in various B-cell and T-cell neoplasms.
- Differentiating angioimmunoblastic T-cell lymphoma (AITL) with Hodgkin/Reed-Sternberg (HRS)-like cells from classic Hodgkin lymphoma (cHL) can be challenging.
Purpose of the Study:
- To evaluate the utility of MUM1/IRF4 protein expression in differentiating AITL with HRS-like cells from cHL.
- To analyze the expression patterns and rosette formation of MUM1/IRF4 in these lymphoma subtypes.
Main Methods:
- Retrospective analysis of 12 cases of AITL with HRS-like cells and 24 cases of cHL.
- Immunohistochemistry (IHC) for MUM1/IRF4 protein was performed on tissue samples.
- Comparison of MUM1/IRF4 expression and rosette formation in neoplastic cells.
Main Results:
- MUM1/IRF4 was expressed in 100% of AITL cases with HRS-like cells, including neoplastic T-cells and HRS-like cells.
- Rosette formation around HRS-like cells was observed in 100% of AITL cases.
- MUM1/IRF4 was expressed in 100% of cHL cases, with rosette formation observed in only 4.2% of cases.
Conclusions:
- MUM1/IRF4 is a highly sensitive marker for both AITL with HRS-like cells and cHL.
- The distinct pattern of rosette formation around HRS-like cells in AITL suggests MUM1/IRF4 can be a valuable tool for differential diagnosis.
- Further investigation into specific expression patterns may refine diagnostic accuracy.
