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Updated: Mar 29, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

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Chronic Lymphocytic Leukemia in the Elderly: Epidemiology and Proposed Patient-Related Approach

Lodovico Balducci1, Dawn Dolan

  • 1Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, FL 33612, USA. Lodovico.Balducci@Moffitt.org.

Cancer Control : Journal of the Moffitt Cancer Center
|December 1, 2015
PubMed

Insights

Older adults with chronic lymphocytic leukemia (CLL) face treatment challenges. Geriatric assessment and new therapies can improve outcomes for elderly CLL patients.

Area of Science:

  • Hematology
  • Geriatrics
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) disproportionately affects the elderly, with most deaths occurring in individuals aged 65 and older.
  • Aging-related comorbidities and functional decline complicate treatment efficacy in older CLL patients.

Purpose of the Study:

  • To review current treatment guidelines and emerging therapies for CLL in older adults.
  • To explore the role of physiological aging and geriatric assessment in managing CLL.

Main Methods:

  • Systematic review of CLL epidemiology, treatment guidelines, and recent therapeutic advancements.
  • Analysis of studies focusing on physiological aging and geriatric assessment in CLL management.

Main Results:

  • Physiological age and comprehensive geriatric assessment are crucial for tailoring CLL treatment in older patients.
  • Older age, indicated by a frailty index, correlates with poorer prognosis in CLL.

Conclusions:

  • Novel therapeutic options show promise in reducing mortality and treatment toxicity for elderly CLL patients.
  • Personalized treatment strategies considering physiological age are essential for improving outcomes in older adults with CLL.
Abstract

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