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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
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[Adherence to entecavir for chronic hepatitis B and correlation with effectiveness]
Vanessa Romero Díaz-Maroto1, Marina Sánchez Cuervo2, Miguel Ángel Rodríguez Sagrado3
1Servicio de Farmacia. Hospital Universitario Ramón y Cajal, Madrid. España.. vanessa.romero@salud.madrid.org.
Summary
Patient adherence to entecavir for chronic hepatitis B is crucial. Lower adherence shows a trend towards virological failure, highlighting the need for improved treatment compliance.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Chronic hepatitis B (CHB) is a significant global health concern.
- Entecavir is a first-line antiviral therapy for CHB.
- Treatment adherence is vital for long-term disease management.
Purpose of the Study:
- To assess patient adherence to entecavir in first-line CHB treatment.
- To investigate the correlation between entecavir adherence and treatment effectiveness.
Main Methods:
- Retrospective observational study (2007-2013).
- Included patients treated with entecavir for ≥ 1 year.
- Defined adherence as median adherence ≥ 95%.
Main Results:
- Median adherence was 94.2%.
- Adherent patients showed a trend towards higher virological response rates (85.7% vs. 71.4%).
- Biochemical response rates were similar between adherent and nonadherent groups.
Conclusions:
- Median adherence to entecavir in CHB patients was suboptimal.
- Nonadherence is associated with a trend towards virological failure.
- Promoting improved adherence is essential for optimizing CHB treatment outcomes.
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