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Objective Analysis of Poly-L-Lactic Acid Injection Efficacy in Different Settings
Sang-Young Byun1, Koo-Il Seo, Jung-Won Shin
1*Department of Dermatology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea; †Modelo Clinic, Seoul, Korea; ‡College of Medicine, Emory University, Atlanta, Georgia.
Summary
Poly-L-lactic acid (PLLA) fillers provide lasting volume enhancement for the cheeks. Different injection schedules with the same total PLLA volume showed similar efficacy and continuous volume effects over 12 months.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Biomaterials
Background:
- Poly-L-lactic acid (PLLA) is a well-established dermal filler known for its collagen-stimulating properties and sustained volume restoration.
- Understanding the optimal injection protocol for PLLA is crucial for maximizing its continuous volume effect.
Purpose of the Study:
- To objectively evaluate the volume effect of Poly-L-lactic acid (PLLA) filler in the cheeks.
- To compare the efficacy of different injection schedules (3 times vs. 2 times) with the same total PLLA volume.
Main Methods:
- A split-face, evaluator-blind randomized study involving 24 volunteers.
- One cheek was injected 3 times with 4 cc total dose, while the other received 2 injections of 6 cc total dose.
- Facial Volume Loss Scale (FVLS) and 3D imaging (Vectra) were used for objective volume assessment.
Main Results:
- Both injection schedules demonstrated statistically significant and continuous volume improvement in the cheeks, sustained up to 12 months.
- Vectra measurements showed comparable volume increases: 2.12 cc to 3.17 cc (3-injection side) and 2.26 cc to 3.19 cc (2-injection side) from 1 to 12 months.
- No significant differences in efficacy or adverse events were observed between the 3-time and 2-time injection schedules.
Conclusions:
- Poly-L-lactic acid (PLLA) filler offers a continuous volume effect for cheek augmentation.
- The number of injections does not significantly impact the overall 12-month volume restoration when the total PLLA volume is consistent.
