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Organophosphorus insecticide poisoning.
1National Poisons Information Service (Birmingham Unit) and West Midlands Poisons Unit, City Hospital Birmingham and University of Birmingham, Birmingham, UK.
BMJ Clinical Evidence
|December 1, 2015
Summary
Oxime treatment is evaluated for acute organophosphorus insecticide poisoning. This systematic overview categorizes the efficacy of oximes compared to placebo or other oximes for treating poisoning.
Area of Science:
- Toxicology
- Pharmacology
- Evidence-Based Medicine
Background:
- Organophosphorus insecticides inhibit acetylcholinesterase, leading to severe symptoms like seizures, coma, and respiratory failure.
- Prognosis is influenced by insecticide dose, toxicity, and individual pharmacokinetics.
Purpose of the Study:
- To systematically review the effects of oxime treatment for acute organophosphorus insecticide poisoning.
- To answer the clinical question regarding the efficacy and safety of oximes in poisoning management.
Main Methods:
- A systematic overview was conducted, searching major databases up to October 2014.
- Included studies were screened, appraised, and evaluated using GRADE methodology for PICO combinations.
Main Results:
- The search identified 25 studies, with 6 full publications evaluated after screening.
- One systematic review update was incorporated into the analysis.
- Efficacy was categorized for oximes versus placebo/no oximes and oximes versus each other.
Conclusions:
- The systematic overview provides categorized efficacy data for oxime treatments in organophosphorus insecticide poisoning.
- Effectiveness and safety of oximes were assessed in comparison to placebo and other oxime treatments.
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