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Summary
The molecular causes of epilepsy remain unknown. However, chronic epilepsy and its treatments disrupt immune balance, affecting antibody levels and suppressing cellular immunity.
Area of Science:
- Neuroimmunology
- Clinical Immunology
Context:
- Epilepsy's link to the immune system is complex.
- Cerebral damage or anticonvulsant drugs can disrupt immune homeostasis.
Purpose:
- To review experimental and clinical immunology in epilepsy.
- To explore the immunological consequences of epilepsy and its treatment.
Summary:
- Experimental models have not identified epilepsy's molecular-immunological cause.
- Clinical studies show altered immune function in epilepsy patients, including a hyperimmune state, reduced immunoglobulins with monotherapy, and anti-tissue antibodies.
- Cellular immunity appears suppressed in epilepsy, irrespective of treatment.
Impact:
- Highlights the significant impact of epilepsy and its management on the immune system.
- Suggests potential avenues for immune-modulating therapies in epilepsy care.