[Immunology of epilepsy]

An idea of the experimental and the clinical immunology of epilepsy has been presented in this paper. Experimental investigations suggest that the causality of epilepsy to molecular-immunological level has not been identified. Clinical observations testify the disordered immunologic homeostasis by primary effect of cerebral damage or, more frequently, by secondary expression of long-term anticonvulsant therapy. The behaviour of humoral immunology in chronic epileptic patients indicates the hiperimmune condition of organism; more evident effect of monotherapy by anticonvulsants on the level (rather lowered) of some immunoglobulins; the presence of anti-tissue antibodies in the absence of known autoimmune diseases. Cell immunity shows the tendency of suppression regardless of the form of epilepsy and its treatment.