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[A controlled study on the action of a new formulation of ambroxol in asthmatiform bronchitis in children]
Insights
Ambroxol and Acetylcysteine effectively treated spastic bronchitis in children. Ambroxol demonstrated a faster onset of action compared to Acetylcysteine for symptom relief.
Area of Science:
- Pediatrics
- Pharmacology
- Respiratory Medicine
Background:
- Spastic bronchitis is a common respiratory condition in children.
- Mucolytic agents like Ambroxol and Acetylcysteine are frequently used to manage symptoms.
Purpose of the Study:
- To compare the efficacy and onset of action of Ambroxol versus Acetylcysteine in pediatric patients with spastic bronchitis.
Main Methods:
- A randomized study involving 28 children (ages 2-13) with spastic bronchitis.
- Patients received either oral Ambroxol (30 mg daily) or Acetylcysteine (200-300 mg daily) for 10 days.
- Symptom assessment included sputum characteristics, expectoration difficulty, cough, dyspnea, and bronchial sounds.
Main Results:
- Both Ambroxol and Acetylcysteine showed significant effectiveness and good tolerability.
- Ambroxol exhibited a more rapid improvement in symptoms compared to Acetylcysteine.
- Key indicators like sputum quality and cough were favorably impacted by both treatments.
Conclusions:
- Ambroxol offers a faster therapeutic response in managing spastic bronchitis in children.
- Both mucolytic agents are viable treatment options, with Ambroxol providing quicker relief.
Abstract:
A comparison between the action of Ambroxol and Acetylcysteine was carried out in 28 children aged 2 to 13 (mean 7 years 3 months) affected with spastic bronchitis. 14 patients were treated daily for 10 days by the oral route with 30 mg of Ambroxol (2 sachets) and 14 with 200-300 mg of Acetylcysteine (2-3 sachets). Quantity and quality of sputum, difficulty in expectorating, cough, dyspnea, bronchial bruits, were assessed before the treatment, 5 days into it and at the end. Both drugs were effective and well tolerated, but Ambroxol proved to be more rapid in achieving a satisfactory improvement than Acetylcysteine.