Related Experiment Video
Updated: Mar 29, 2026
High-Density Lipoprotein-Specific Phospholipid Efflux Assay
Published on: September 30, 2025
Lipid Profile in Post-Acute Coronary Syndrome Setting: Lipidic Risk Assessment in Young People beyond LDL-C
1Dr Gana Pati Aditya, Assistant Professor, Department of Cardiology, Mymensingh Medical College, Mymensingh, Bangladesh;
Insights
Apolipoprotein B (Apo B) levels are better predictors of acute coronary syndrome (ACS) risk in young adults than traditional lipid profiles. Elevated Apo B identifies individuals at risk, even with normal LDL-C levels.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Clinical Diagnostics
Background:
- Acute coronary syndrome (ACS) is a significant health concern, particularly in younger populations.
- Traditional lipid profiles, including LDL-C, may underestimate ACS risk in certain individuals.
- Apolipoprotein B (Apo B) is a key component of atherogenic lipoproteins and may offer a more sensitive marker for cardiovascular risk.
Purpose of the Study:
- To investigate the role of Apolipoprotein B (Apo B) in predicting acute coronary syndrome (ACS) in young adults.
- To compare the predictive value of Apo B with conventional lipid parameters (TC, HDL-C, LDL-C, non-HDL-C) for ACS risk.
- To determine if Apo B can identify individuals at risk for ACS who have normal LDL-C levels.
Main Methods:
- A case-control study involving 50 young adults (18-45 years) with their first ACS event and 50 age- and sex-matched healthy controls.
- Analysis of lipid parameters including total cholesterol (TC), HDL-C, LDL-C, non-HDL-C, and Apolipoprotein B (Apo B).
- Multivariate analysis was employed to identify independent determinants of ACS.
Main Results:
- Cases with ACS had significantly lower TC, HDL-C, LDL-C, and non-HDL-C compared to controls.
- Apo B levels were significantly higher in ACS cases (98.7±25.1 mg/dl) than in controls (77.5±35.2 mg/dl).
- 50% of ACS cases with hyper Apo B had normal LDL-C levels, indicating underestimation of risk by conventional profiles.
- Apo B was identified as an independent determinant of ACS in multivariate analysis.
- Among controls, 46% with high LDL-C also had hyper Apo B, suggesting future ACS risk.
Conclusions:
- Apolipoprotein B (Apo B) is a more effective predictor of acute coronary syndrome (ACS) risk in young adults than standard lipid profiles.
- Elevated Apo B levels can identify individuals at risk for ACS, even when LDL-C levels are within the normal range.
- Measuring Apo B can help assess basal or residual ACS risk in young people, providing insights not obtainable from calculated LDL-C alone.
Abstract:
This case-control study was carried out in Department of Cardiology, Mymensingh Medical College Hospital, Bangladesh, within the period from June 2009 to May 2010. A total 50 case of 18-45 years of age with first attack of acute coronary syndrome admitted in coronary care unit and 50 healthy controls of same age and sex distribution were studied. Among the lipid parameters, TC, HDL-C, LDL-C and non-HDL-C were significantly lower in cases than in controls. Apo B was significantly higher in the cases (98.7±25.1 mg/dl vs. 77.5±35.2 mg/dl in control). Importantly, among the cases with hyper Apo B condition, 25 (50.0%) had LDL-C level within normal limit, thus conventional lipid profile underestimated the ACS risk. In multivariate analysis Apo B was an independent determinant of ACS. Among the controls 23(46.0%) with high LDL-C had hyper Apo condition. Hyper-Apo B in these controls may cause acute coronary syndrome in future. The present study shows estimation of Apo B can predict basal or residual risk of acute coronary syndrome in young people, what from calculated LDL-C level cannot be inferred.
More Related Videos
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
09:15Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:30Acute Coronary Syndrome I: Introduction
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:26Atherosclerosis III: Management
01:28Acute Coronary Syndrome IV: Interprofessional Care