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Corrected Version: Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate.

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RETRACTED: Rangasamy et al. Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 2083.

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PPARα in lysosomal biogenesis: A perspective.

Arunava Ghosh1, Kalipada Pahan2

  • 1Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States.

Pharmacological Research
|December 2, 2015
PubMed
Summary

Lysosomes regulate cellular processes beyond waste removal. New research shows peroxisomal proliferator activated receptor alpha (PPARα) activation links lysosomal biogenesis to lipid metabolism, suggesting a two-way street.

Keywords:
Fibrate drugsLipid metabolismLysosomal biogenesisPPARαTFEB

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Area of Science:

  • Cell Biology
  • Metabolism

Background:

  • Lysosomes, traditionally viewed as cellular waste disposal units, are now recognized for diverse roles including development, programmed cell death, and lipid metabolism.
  • Transcription Factor EB (TFEB) is a master regulator of lysosomal biogenesis.
  • Peroxisomal proliferator activated receptor alpha (PPARα) is a key regulator of lipid metabolism.

Discussion:

  • This study investigates the regulation of TFEB by PPARα activation.
  • It explores the connection between lysosomal biogenesis and lipid metabolism.
  • The findings suggest a potential bi-directional interplay between these cellular processes.

Key Insights:

  • PPARα activation directly influences TFEB, impacting lysosomal biogenesis.
  • Lysosomal biogenesis and lipid metabolism are interconnected, particularly under PPARα activation.
  • A novel regulatory link between lipid metabolism and lysosomal function is proposed.

Outlook:

  • Further research can elucidate the precise mechanisms of this bi-directional communication.
  • Understanding this interplay may reveal new therapeutic targets for metabolic and lysosomal storage diseases.
  • This work opens avenues for exploring lysosome-lipid metabolism crosstalk in various physiological and pathological conditions.