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Updated: Mar 29, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Generation of Induced Pluripotent Stem Cells from Mammalian Endangered Species
Inbar Friedrich Ben-Nun1, Susanne C Montague2, Marlys L Houck3
1Department of Chemical Physiology, Center for Regenerative Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. fbninbar@gmail.com.
Abstract:
For some highly endangered species there are too few reproductively capable animals to maintain adequate genetic diversity, and extraordinary measures are necessary to prevent their extinction. Cellular reprogramming is a means to capture the genomes of individual animals as induced pluripotent stem cells (iPSCs), which may eventually facilitate reintroduction of genetic material into breeding populations. Here, we describe a method for generating iPSCs from fibroblasts of mammalian endangered species.
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