Related Experiment Video
Updated: Mar 29, 2026
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
Association of Helicobacter pylori antibodies and severity of migraine attack
Behnaz Ansari1, Keivan Basiri1, Rokhsareh Meamar2
1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background:
Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO).
Methods:
This is a case-control study containing information on 84 patients (including MA, MO) and 49 healthy individuals. The enzyme-linked immunosorbent assay (ELISA) test was used to measure immunoglobulin G (IgG,) immunoglobulin M (IgM) titer in two groups. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire.
Results:
Mean ± SD of IgM antibody in Migrainous patients 26.3 (23.1) showed significantly difference with control group 17.5 (11.2) (P = 0.004). In addition, the mean ± SD HIT6 in Migrainous patients differed significantly between MA and MO groups 65.5 (4.7), 54.9 (5.3) respectively, P < 0.001). The only significant correlation was found for IgG antibody and HIT6 in MA patients (r = 0.407, P = 0.011) and MO group (r = 0.499, P = 0.002). The risk of migraine occurrence in patients did not significantly associate with the level of IgG and IgM antibodies.
Conclusion:
The results give a hope that definite treatment and eradication of this bacterium could be a cure or to reduce the severity and course of migraine headaches.
Insights
Helicobacter pylori infection may be linked to migraine headaches. Eradicating this bacterium could potentially reduce migraine severity and frequency.
Area of Science:
- Neurology
- Gastroenterology
- Infectious Diseases
Background:
- Emerging research suggests a link between Helicobacter pylori infection and migraine headaches.
- Helicobacter pylori (H. pylori) is a common bacterial infection.
- Migraine is a prevalent neurological disorder characterized by severe headaches.
Purpose of the Study:
- To investigate the association between H. pylori infection and migraine with aura (MA) and without aura (MO).
- To evaluate the role of H. pylori infection in the pathogenesis of different migraine types.
Main Methods:
- A case-control study involving 84 migraine patients (MA and MO) and 49 healthy controls.
- Enzyme-linked immunosorbent assay (ELISA) was used to measure immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody titers.
- Headache severity was assessed using the Headache Impact Test (HIT-6) questionnaire.
Main Results:
- Migraine patients showed significantly higher mean IgM antibody levels compared to controls (P = 0.004).
- Headache Impact Test (HIT-6) scores were significantly higher in MA patients than MO patients (P < 0.001).
- A significant correlation was observed between IgG antibody levels and HIT-6 scores in both MA (r = 0.407, P = 0.011) and MO (r = 0.499, P = 0.002) groups.
Conclusions:
- The findings suggest a potential role of H. pylori infection in migraine headaches.
- Treatment and eradication of H. pylori may offer a therapeutic strategy to alleviate migraine symptoms.
- Further research is warranted to confirm the causal relationship and optimize treatment approaches.
More Related Videos
10:44One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
Published on: June 18, 2016
05:13Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
Published on: June 13, 2025
Related Concept Videos
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:27Peptic Ulcer
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...