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Fosfomycin: Uses and potentialities in veterinary medicine
D S Pérez1, M O Tapia1, A L Soraci1
1Laboratorio de Toxicología, Centro de Investigación Veterinaria de Tandil, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina ; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Open Veterinary Journal
|December 2, 2015
Summary
Fosfomycin (FOS) is a broad-spectrum antibiotic effective against Gram-positive and Gram-negative bacteria. Its unique properties and low toxicity make it a promising option for treating bacterial infections in both humans and animals.
Area of Science:
- Microbiology
- Pharmacology
- Veterinary Medicine
Background:
- Fosfomycin (FOS) is a natural bactericidal antibiotic with broad-spectrum activity.
- It inhibits bacterial cell wall synthesis and exhibits synergistic effects with other antibiotics.
- FOS possesses unique properties including biofilm penetration, immunomodulatory effects, and protection against drug-induced nephrotoxicity.
Purpose of the Study:
- To provide animal health practitioners with comprehensive information on Fosfomycin (FOS).
- To highlight the potential of FOS as a promising antimicrobial agent in veterinary medicine.
- To discuss the drug's properties, efficacy, and applications in both human and animal health.
Main Methods:
- Review of existing literature on Fosfomycin (FOS) properties and applications.
- Analysis of pharmacokinetic profiles and bioavailability across different species and salt forms.
- Examination of FOS efficacy in treating various bacterial infections in humans and animals.
Main Results:
- FOS demonstrates bactericidal activity against Gram-positive and Gram-negative bacteria.
- The antibiotic exhibits good diffusion into body fluids and tissues due to low molecular weight and high water solubility.
- FOS has shown efficacy in treating infections like E. coli and Salmonella spp. in broilers and various bacterial infections in piglets.
Conclusions:
- Fosfomycin (FOS) is a versatile antibiotic with low toxicity and broad-spectrum efficacy.
- Its unique pharmacokinetic properties and demonstrated efficacy in human medicine suggest significant potential for veterinary applications.
- Further recognition and utilization of FOS in veterinary medicine are warranted for treating diverse bacterial infections.
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