Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The link between cholesterol and atherosclerosis: intervention trials].

H Milon, E Desjoyaux, B Pierrard

    La Revue Du Praticien
    |April 20, 1989
    PubMed
    Summary

    Lowering blood cholesterol through medication can decrease coronary heart disease incidence over time. However, overall mortality benefits remain debated due to non-cardiovascular causes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gas chromatography-mass spectrometric determinations of abscisic acid levels in the cap and the apex of maize roots.

    Planta·2014
    Same author

    Transiliac hernia after bone graft.

    Journal of visceral surgery·2013
    Same author

    Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism.

    Progress in lipid research·2013
    Same author

    Hypertriglyceridaemic insulin-resistant obese dog model: effects of high-fat diet depending on age.

    Journal of animal physiology and animal nutrition·2008
    Same author

    Arterial stiffness is associated with left atrial size in hypertensive patients.

    Archives of cardiovascular diseases·2008
    Same author

    Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity.

    Journal of animal physiology and animal nutrition·2004

    Area of Science:

    • Cardiovascular Science
    • Medical Research

    Context:

    • Atherosclerosis intervention trials aim to reduce blood cholesterol.
    • Two trial types exist: clinical consequence evaluation and arteriography-based disease study.

    Purpose:

    • To assess the impact of cholesterol-lowering interventions on atherosclerosis progression and clinical outcomes.
    • To evaluate the efficacy and controversies surrounding atherosclerosis treatment.

    Summary:

    • Trials focusing on clinical consequences show reduced coronary disease incidence after 5+ years of treatment.
    • Direct visualization trials suggest delayed atheromatous lesion development.
    • Secondary prevention studies yielded mixed results, possibly due to late intervention or insufficient cholesterol reduction.

    Related Experiment Videos

    Impact:

    • Experimental results reinforce the pathogenic role of atherosclerosis.
    • Clinical implementation of cholesterol-lowering measures is debated due to lack of overall mortality reduction and non-cardiovascular mortality concerns.