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Pyrrole-Imidazole Polyamides: Automated Solid-Phase Synthesis
Lijing Fang1, Zhengyin Pan1, Paul M Cullis2
1Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, People's Republic of China.
Current Protocols in Nucleic Acid Chemistry
|December 2, 2015
Abstract:
In this unit, the fully automated solid-phase synthetic strategy of hairpin Py-Im polyamides is described using triphosgene (BTC) as a coupling agent. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in 9% to 20% yield in 3 days.
