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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
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Recurrent Nocardia Sepsis in a Patient With Sickle Cell Anemia Receiving Continuous Deferoxamine
Jacob M Wessler1, Daniel J Adams2, Anjali N Kunz3
1Department of Pediatric Hematology/Oncology.
Journal of the Pediatric Infectious Diseases Society
|December 2, 2015
Summary
Nocardia sepsis can recur in immunocompromised patients. This case highlights recurrent Nocardia sepsis in a patient with sickle cell disease receiving deferoxamine therapy.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Nocardia species are common soil bacteria.
- Invasive Nocardia infections typically occur in immunocompromised individuals, particularly those with impaired cell-mediated immunity.
- Sickle cell disease and iron overload are risk factors for certain infections.
Purpose of the Study:
- To report a case of recurrent Nocardia sepsis.
- To investigate the potential role of deferoxamine therapy in Nocardia infections.
- To highlight the importance of considering Nocardia in patients with specific risk factors.
Main Methods:
- Case report of a patient with sickle cell disease and iron overload.
- Description of recurrent Nocardia sepsis episodes.
- Review of patient's treatment, including high-dose deferoxamine infusions via central venous catheter.
Main Results:
- The patient experienced recurrent episodes of Nocardia sepsis.
- The sepsis occurred during high-dose deferoxamine infusions.
- This suggests a potential link between deferoxamine therapy and Nocardia infections in susceptible individuals.
Conclusions:
- Recurrent Nocardia sepsis can occur in patients with sickle cell disease and iron overload.
- Deferoxamine therapy, especially with central venous catheter use, may increase the risk of Nocardia infections.
- Clinicians should maintain a high index of suspicion for Nocardia in similar patient populations.
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