Related Experiment Video

Updated: Mar 29, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.8K

Genetic Variation in MicroRNAs and Risk of Oral Squamous Cell Carcinoma in South Indian Population

P S Sushma1, Kaiser Jamil, P Uday Kumar

  • 1Department of Pathology, National Institute of Nutrition (ICMR), Hyderabad, Telangana, India

Asian Pacific Journal of Cancer Prevention : APJCP
|December 3, 2015
PubMed
Abstract

Insights

Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, specifically miR-196a2C>T and miR-149C>T, are associated with oral squamous cell carcinoma (OSCC) risk in South India. The CC genotype of miR-196a2 and CT/TT genotypes of miR-149 showed significant links to OSCC development.

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key regulators in cancer development.
  • Single nucleotide polymorphisms (SNPs) in miRNA genes can alter gene expression and function.
  • Oral squamous cell carcinoma (OSCC) is a significant health concern, particularly in South India.

Purpose of the Study:

  • To investigate the association between miR-149C>T and miR-196a2C>T polymorphisms and the susceptibility to OSCC in a South Indian population.
  • To determine if specific genotypes of these miRNA SNPs are risk factors for OSCC.

Main Methods:

  • Case-control study involving 100 OSCC patients and 102 healthy controls from South India.
  • Genotyping of miR-149C>T and miR-196a2C>T polymorphisms using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP).

Main Results:

  • The CC genotype of miR-196a2 polymorphism was significantly associated with an increased risk of OSCC.
  • CT and TT genotypes of miR-149 polymorphism were also found to be significantly associated with OSCC susceptibility (p = 0.05 and p = 0.07, respectively).
  • Genotype frequencies differed notably between OSCC patients and healthy controls for both polymorphisms.

Conclusions:

  • The miR-196a2C>T and miR-149C>T polymorphisms are potential genetic markers for OSCC risk in the South Indian population.
  • These miRNA SNPs may play a role in the pathogenesis of oral squamous cell carcinoma.

More Related Videos

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

7.2K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.4K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

12.0K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
19.2K
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
7.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.8K