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The SV40 small t antigen is essential for the morphological transformation of human fibroblasts
A de Ronde1, C J Sol, A van Strien
1Department of Virology, Academic Medical Centre, Amsterdam, The Netherlands.
Virology
|July 1, 1989
Abstract:
The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts.