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MicroRNA-124 rs531564 Polymorphism and Cancer Risk: A Meta-analysis

Wen-Jing Li1, Yong Wang, Yu Gong

  • 1Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital, Changzhou, China

Asian Pacific Journal of Cancer Prevention : APJCP
|December 3, 2015
PubMed

Insights

The miR-124 rs531564 C > G polymorphism is linked to reduced cancer risk, particularly in the Chinese population. This genetic variation shows significant associations with decreased risks across various cancer types.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • MicroRNA-124 (miR-124) plays a role in cellular processes.
  • A specific polymorphism, rs531564 (C > G), has been identified in the miR-124 gene.

Purpose of the Study:

  • To investigate the association between the miR-124 rs531564 polymorphism and cancer risk.
  • To conduct a meta-analysis of existing studies.

Main Methods:

  • A comprehensive literature search was performed across Medline, Embase, and Wangfang Medicine databases.
  • Relevant studies investigating the miR-124 rs531564 polymorphism and cancer risk were included in the meta-analysis.

Main Results:

  • The miR-124 rs531564 polymorphism was significantly associated with decreased cancer risks in allelic, homozygote, dominant, and recessive models.
  • Stratified analysis for cervical cancer showed significant associations in the allelic and dominant models.
  • Subgroup analysis indicated a decreased risk for esophageal squamous cell carcinoma in the homozygote and recessive models.

Conclusions:

  • The miR-124 rs531564 C > G polymorphism is a significant protective factor against various cancers.
  • This polymorphism is particularly relevant for cancer risk assessment in the Chinese population.

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