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Updated: Mar 29, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors
1Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts. aiafrate@partners.org.
Abstract:
The article by Rodig and colleagues, which was published in the August 15, 2009, issue of Clinical Cancer Research, helped detail the clinicopathologic profile of ALK-positive tumors and initiated the development of ALK diagnostics. Subsequent clinical trials utilized these findings, resulting in the approval of effective targeted therapies. The ALK story is a model for the development of therapies in the genomic era.
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