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Antithrombotic Effects of Amaranthus hypochondriacus Proteins in Rats
Ana Clara Sabbione1,2, Gustavo Rinaldi3, María Cristina Añón1,2
1Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA), Calle 47 y 116, 1900, La Plata, Argentina.
Insights
Amaranth proteins show potential as an antithrombotic agent, inhibiting thrombus formation without affecting bleeding time in rats. Further research confirmed these findings in ex-vivo assays, suggesting dietary benefits for cardiovascular health.
Area of Science:
- Biochemistry
- Pharmacology
- Nutritional Science
Background:
- Cardiovascular disease (CVD) poses a significant global health burden.
- Dietary antithrombotic components offer a promising strategy for CVD prevention.
- Amaranthus hypochondriacus proteins are being investigated for their potential health benefits.
Purpose of the Study:
- To evaluate the in vivo and ex vivo effects of Amaranthus hypochondriacus proteins on platelet plug formation.
- To assess the impact of amaranth proteins on the coagulation cascade.
- To determine the antithrombotic potential of amaranth proteins.
Main Methods:
- Oral administration of amaranth proteins to rats.
- Determination of bleeding time.
- Analysis of platelet aggregation and coagulation parameters using a hemostatometer, thrombin time (TT), and activated partial thromboplastin time (APTT).
Main Results:
- No significant difference in bleeding time was observed between amaranth protein-treated rats and controls.
- Hemostatometer analysis showed approximately double the values in amaranth-treated rats, indicating inhibited thrombus formation.
- Clotting tests revealed a 17% increase in TT and a 14% increase in APTT in amaranth-treated rats compared to controls.
Conclusions:
- Amaranthus hypochondriacus proteins demonstrate a potential antithrombotic effect.
- These proteins may inhibit thrombus formation by influencing the coagulation cascade.
- Dietary amaranth proteins could serve as a natural agent for cardiovascular disease prevention.
Abstract:
Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess in vivo and ex vivo effects of Amaranthus hypochondriacus proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The ex-vivo assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.
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