Related Experiment Video
Updated: Mar 29, 2026

Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
Published on: April 25, 2025
The Optical Rotation of Glucose Prototypes: A Local or a Global Property?
Clarissa O da Silva1, Benedetta Mennucci1
1Departamento de Química, UFRuralRJ, BR456 km 47, Rio de Janeiro, Brazil, and Dipartimento di Chimica e Chim. Ind., Università degli Studi di Pisa, via Risorgimento 35, Pisa, Italy.
Abstract:
In this work, we present a quantum-mechanical study of the optical rotation (OR) of model systems representing glucose prototypes with one and two chiral centers. The ONIOM method is used to evaluate the property and to analyze its local or global character. Different ONIOM partitions are tested and compared to better appreciate differences and similarities between mono- and bichiral prototypes. The local versus global character of OR is investigated and compared to other properties such as energies and nuclear magnetic shieldings, which have been deeply studied in previous applications of the ONIOM method.
Related Concept Videos
Properties of Enantiomers and Optical Activity
Fischer Projections
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Absorption Into the Small Intestine
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Gyroscope

