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Related Concept Videos

Aggression01:47

Aggression

30.6K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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X-Inactivation01:58

X-Inactivation

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The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
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Conduct Disorder01:28

Conduct Disorder

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Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
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X-linked Traits01:19

X-linked Traits

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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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Fixed Action Patterns01:06

Fixed Action Patterns

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A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
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Related Experiment Video

Updated: Mar 29, 2026

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
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A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

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Aggression in fragile X syndrome.

A C Wheeler1, M Raspa1, E Bishop1

  • 1RTI International, Research Triangle Park, NC, USA.

Journal of Intellectual Disability Research : JIDR
|December 3, 2015
PubMed
Summary

Aggressive behavior is common in fragile X syndrome (FXS), affecting most males and females. Sensory issues and anxiety are key predictors, suggesting a link to escaping uncomfortable situations.

Area of Science:

  • Neurodevelopmental Disorders
  • Behavioral Science
  • Genetics

Background:

  • Fragile X syndrome (FXS) is associated with behavioral challenges, particularly in males.
  • Limited research exists on the prevalence, nature, and consequences of aggression in FXS.

Purpose of the Study:

  • To investigate the prevalence, frequency, severity, and predictors of aggressive behavior in individuals with FXS.
  • To understand the impact of aggression and effective management strategies in FXS.

Main Methods:

  • Survey methodology employed to collect caregiver reports.
  • Data gathered on types, frequency, and severity of aggressive behavior in 774 individuals with FXS.

Main Results:

  • Over 90% of males and females with FXS exhibited aggression in the past year.
Keywords:
aggressionfragile X syndrome

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TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
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  • Moderate to severe aggression or treatment for aggression reported in a third of males and nearly 20% of females.
  • Sensory issues and hyperactivity predicted aggression frequency; sensory issues and anxiety predicted severity. Aggression in males led to caregiver or peer injuries in 30% and 22% of cases, respectively.

    • Conclusions:

    • Aggressive behaviors are a significant concern in a subset of individuals with FXS.
    • Sensory concerns predict both frequency and severity, suggesting aggression may be a response to uncomfortable stimuli.