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Updated: Mar 29, 2026
Implanting Glass Spinal Cord Windows in Adult Mice with Experimental Autoimmune Encephalomyelitis
Published on: December 21, 2013
Ocular nerve growth factor administration (oNGF) affects disease severity and inflammatory response in the brain of
Valentina Carito1,1, Sara De Nicolò1,1, Marco Fiore1,1
1Institute of Cell Biology and Neurobiology, National Research Council (CNR/IRCCS) Santa Lucia Foundation, Via del Fosso di Fiorano, 64 (00143) Rome, Italy.
Abstract:
The rat acute experimental autoimmune encephalomyelitis (EAE) model was used to investigate the effects of ocularly administered nerve growth factor (oNGF) on disease development and brain inflammation. It was found that oNGF affects clinical scores. However, EAE rats receiving oNGF treatment showed reduced expression of pro-inflammatory cytokines and chemokines in the cerebellum and the hippocampus, but not in the frontal cortex. These data confirm the ability of oNGF to counteract the effects of EAE in the brain and suggest a role for oNGF in the regulation of local inflammatory responses observed in the acute phase of EAE.
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