[Serum immunoglobulin levels in patients with hemoblastoses]

Content of serum immunoglobulins (Ig) was estimated in patients with various types of hemoblastoses by radial immunodiffusion. Reactive alterations in content of Ig were observed in several patients with acute leukosis and chronic myeloleukosis. In patients with chronic lympholeukosis the decrease in concentration of serum Ig was manifested as a syndrom of the antibodies insufficiency. Monoclonic type of IgM or the reactive increase in Ig content was found only in several cases of chronic lympholeukosis. Lymphogranulomatosis and other malignant lymphomas were inhirent in the distinct increase of Ig and primarily of IgG. Content of normal Ig was distinctly decreased and monoclonic Ig (paraprotein) was found in paraproteinemic hemoblastoses. The observed alterations in the Ig content under hemoblastoses are of diagnostic and prognostic importance.