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Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

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Ketoprofen Dental Pain Study.

L M Levin¹, S A Cooper, N J Betts

¹University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.

The Journal of Clinical Dentistry

|December 4, 2015

Summary

This summary is machine-generated.

This study found that both 12.5 mg and 37.5 mg doses of ketoprofen effectively reduced post-surgical dental pain compared to placebo. Ketoprofen is a safe and effective over-the-counter (OTC) analgesic for managing this type of pain.

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Area of Science:

Pharmacology
Pain Management
Dental Surgery

Background:

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is now available over-the-counter (OTC) at 12.5 mg.
Post-surgical pain following impacted third molar extraction is a common and significant clinical issue.

Purpose of the Study:

To evaluate the analgesic efficacy and safety of ketoprofen 12.5 mg and 37.5 mg for post-operative dental pain.
To compare these dosages against a placebo in a randomized, double-blind study.

Main Methods:

Single-dose, double-blind, randomized, placebo-controlled trial with a 6-hour inpatient evaluation.
Patients received ketoprofen 12.5 mg (n=30), ketoprofen 37.5 mg (n=32), or placebo (n=15) for moderate to severe pain.
Pain intensity and relief were measured using visual analog scales (VAS) and categorical scales (CAT) at regular intervals.

Main Results:

Both ketoprofen dosages were significantly more efficacious than placebo (p < 0.05).
The 12.5 mg dose showed superiority for pain intensity difference (PID) and pain relief from 1-3 hours.
The 37.5 mg dose demonstrated superiority from 40 minutes to 4 hours; it was also superior to 12.5 mg at specific early time points.
Both doses showed significant summary analgesic measures (SPID, TOTPAR) over 3, 4, and 6 hours compared to placebo, with one exception.

Conclusions:

Ketoprofen, in doses ranging from 12.5 mg to 37.5 mg, is a safe and effective analgesic for post-operative dental pain.
The study supports the use of ketoprofen as an OTC option for managing pain after impacted third molar removal.