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Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Tau in physiology and pathology.

Yipeng Wang^1,2, Eckhard Mandelkow^1,2,3

¹German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.

Nature Reviews. Neuroscience

|December 4, 2015

Summary

Tau protein stabilizes neurons but aggregates in neurodegenerative diseases called tauopathies. Recent research reveals new brain functions of tau in health and disease.

Area of Science:

Neuroscience
Molecular Biology
Biochemistry

Background:

Tau is a natively unfolded protein crucial for stabilizing neuronal microtubules and axonal outgrowth.
While typically soluble and non-aggregating, tau aggregation is a hallmark of neurodegenerative tauopathies.
Understanding tau's role is key to deciphering neurodegeneration mechanisms.

Purpose of the Study:

To review the expression, post-translational modifications, and functions of tau.
To explore tau's roles in both normal brain physiology and disease pathophysiology.
To highlight recent advancements in tau research.

Main Methods:

Literature review of existing studies on tau protein.
Analysis of research on tau expression patterns.

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Examination of studies on tau post-translational modifications and functional roles.

Main Results:

Tau protein has diverse physiological functions in the brain beyond microtubule stabilization.
Specific post-translational modifications influence tau's aggregation propensity and cellular functions.
Tau pathology is implicated in the progression of various neurodegenerative disorders.

Conclusions:

Tau protein plays a complex role in neuronal health and disease.
Further research into tau's functions and modifications is critical for understanding and treating tauopathies.
Targeting tau pathology may offer therapeutic strategies for neurodegenerative diseases.