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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
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Current concepts for PrEP adherence in the PrEP revolution: from clinical trials to routine practice
1aCenter for Global Health, Massachusetts General Hospital bDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Current Opinion in HIV and AIDS
|December 4, 2015
Summary
Adherence to oral pre-exposure prophylaxis (PrEP) is generally high in real-world settings, offering reliable HIV prevention. Future efforts should focus on context-specific adherence goals aligned with individual HIV risk and prevention choices.
Area of Science:
- Public Health
- Infectious Disease Prevention
- Pharmacology
Background:
- Oral pre-exposure prophylaxis (PrEP) is a key biomedical strategy for HIV prevention.
- Understanding and optimizing adherence to PrEP is crucial for its effectiveness in real-world settings.
- Adherence measurement and support strategies require ongoing evaluation and refinement.
Purpose of the Study:
- To review the current understanding of adherence to oral PrEP.
- To examine methods for measuring PrEP adherence.
- To discuss approaches for supporting PrEP adherence and defining adherence goals within HIV prevention.
Main Methods:
- Literature review of studies on PrEP adherence.
- Analysis of adherence rates in clinical trials, extensions, and demonstration projects.
- Exploration of adherence monitoring technologies and intervention strategies.
Main Results:
- PrEP adherence has been higher in recent trials and demonstration projects compared to initial clinical trials.
- Adherence monitoring has explored electronic pill containers, SMS reminders, and drug concentrations.
- Interventions include enhanced counseling, objective adherence feedback, and SMS support.
- The conceptualization of PrEP adherence is shifting from 100% to context-dependent goals based on HIV exposure risk.
Conclusions:
- PrEP adherence outside of clinical trials is generally sufficient for effective HIV prevention.
- Future efforts should prioritize measuring and supporting adherence based on individual HIV risk and dynamic prevention choices.
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