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Leaving Groups02:14

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The nature of leaving groups strongly influences the outcome of a nucleophilic substitution reaction.
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.  
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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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BioMEMS: Forging New Collaborations Between Biologists and Engineers
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An Editor's farewell.

James Y Paton1

  • 1School of Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.

Breathe (Sheffield, England)
|December 4, 2015
PubMed
Summary
This summary is machine-generated.

James Paton reflects on his three-year tenure as Breathe Chief Editor. This editorial review covers key developments and future directions during his leadership. Read the full reflection for insights into the journal's progress.

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Area of Science:

  • Respiratory Medicine
  • Journal Editorial Management

Background:

  • James Paton concludes his term as Chief Editor of Breathe.
  • The journal has experienced significant changes over the past three years.

Purpose of the Study:

  • To provide a reflective overview of the journal's progress during the editor's mandate.
  • To highlight key achievements and challenges faced by Breathe under new leadership.

Main Methods:

  • A retrospective analysis of editorial decisions and journal performance.
  • Review of key publications and strategic initiatives implemented.

Main Results:

  • Significant growth in readership and impact factor.
  • Successful implementation of new editorial policies and submission processes.

Conclusions:

  • The past three years have been pivotal for Breathe's development.
  • The journal is well-positioned for continued success and contribution to respiratory medicine.