Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel effect of parylene-based surface coating on HepG2 cell function.

Materials science & engineering. C, Materials for biological applications·2014
Same author

Histone modifications associated with cancer cell migration and invasion.

Methods in molecular biology (Clifton, N.J.)·2014
Same author

Arthritis and bacteremia due to Leclercia adecarboxylata.

Internal medicine (Tokyo, Japan)·2014
Same author

An on-chip small intestine-liver model for pharmacokinetic studies.

Journal of laboratory automation·2014
Same author

Coordinated expression of H3K9 histone methyltransferases during tooth development in mice.

Histochemistry and cell biology·2014
Same author

Visualization of epigenetic modifications in preimplantation embryos.

Methods in molecular biology (Clifton, N.J.)·2014

Related Experiment Video

Updated: Mar 29, 2026

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes
08:31

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

Published on: September 13, 2018

10.5K

Surface modification on polydimethylsiloxane-based microchannels with fragmented poly(l-lactic acid) nanosheets.

Lu Yang1, Yosuke Okamura, Hiroshi Kimura

  • 1Micro/Nano Technology Center, Tokai University , 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.

Biomicrofluidics
|December 4, 2015
PubMed
Summary

We developed a simple patchwork method to modify polydimethylsiloxane (PDMS) microfluidic channels using poly(l-lactic acid) (PLLA) nanosheets. This technique prevents platelet adhesion, offering a novel solution for biomedical applications.

More Related Videos

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication
07:01

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication

Published on: July 18, 2025

2.6K
Micropunching Lithography for Generating Micro- and Submicron-patterns on Polymer Substrates
09:24

Micropunching Lithography for Generating Micro- and Submicron-patterns on Polymer Substrates

Published on: July 2, 2012

15.7K

Related Experiment Videos

Last Updated: Mar 29, 2026

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes
08:31

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

Published on: September 13, 2018

10.5K
Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication
07:01

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication

Published on: July 18, 2025

2.6K
Micropunching Lithography for Generating Micro- and Submicron-patterns on Polymer Substrates
09:24

Micropunching Lithography for Generating Micro- and Submicron-patterns on Polymer Substrates

Published on: July 2, 2012

15.7K

Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Surface Chemistry

Background:

  • Surface modification of polydimethylsiloxane (PDMS) is crucial for microfluidic devices.
  • Existing methods often involve complex chemistry or organic solvents, causing PDMS swelling.
  • Preventing biofouling, particularly platelet adhesion, is essential for many microfluidic applications.

Purpose of the Study:

  • To develop a simple and effective surface modification technique for PDMS microfluidic devices.
  • To utilize poly(l-lactic acid) (PLLA) nanosheets for PDMS surface functionalization.
  • To assess the anti-adhesion properties of the modified PDMS surface, especially concerning platelets.

Main Methods:

  • A novel patchwork technique was employed to adhere fragmented poly(l-lactic acid) (PLLA) nanosheets onto PDMS microchannels.
  • The method leveraged the inherent adhesiveness of PLLA nanosheets.
  • No complex chemical modifications or organic solvents were required, avoiding PDMS swelling.

Main Results:

  • The PLLA nanosheet modification was successfully achieved on PDMS microchannels.
  • The modified PDMS surfaces demonstrated a significant reduction in platelet adhesion and activation.
  • The technique proved to be simple, efficient, and free from PDMS swelling issues.

Conclusions:

  • A straightforward and solvent-free method for modifying PDMS microfluidic devices using PLLA nanosheets has been established.
  • The modified PDMS surfaces exhibit excellent hemocompatibility by preventing platelet adhesion.
  • This technique offers a promising approach for fabricating specialized microfluidic devices for biological, medical, and hematological applications.