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Stromal Targets for Fluorescent-Guided Oncologic Surgery.

Martin C Boonstra1, Jai Prakash2, Cornelis J H Van De Velde1

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Frontiers in Oncology
|December 5, 2015
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Image-guided oncologic surgery (IGOS) uses fluorescent probes to help surgeons differentiate tumors from healthy tissue during operations. Targeting tumor stroma offers advantages for improved visualization and surgical precision.

Keywords:
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Area of Science:

  • Oncology
  • Surgical Imaging
  • Biotechnology

Background:

  • Pre-operative imaging is crucial for tumor diagnosis but limited during surgery.
  • Image-guided oncologic surgery (IGOS) enhances intraoperative tumor visualization.
  • Current IGOS probes are not widely available, with ongoing clinical trials.

Purpose of the Study:

  • To explore the potential of IGOS in oncologic surgery.
  • To evaluate targeting tumor stroma as a strategy for IGOS probe development.
  • To highlight the advantages of stromal targeting for enhanced tumor visualization.

Main Methods:

  • Utilizing near-infrared fluorescent dyes conjugated to targeting agents.
  • Developing specific probes for identifying tumor and vital structures.
  • Investigating probes targeting malignant cells versus stromal cells.

Main Results:

  • IGOS assists surgeons in distinguishing tumor from normal tissue.
  • Targeting stromal cells presents advantages for IGOS probe development.
  • Stromal targets are often universally expressed and located at tumor periphery.

Conclusions:

  • IGOS holds significant promise for improving oncologic surgery outcomes.
  • Targeting tumor stroma is a viable and advantageous strategy for developing effective IGOS probes.
  • Further development and clinical trials are needed for widespread IGOS adoption.