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Anal Sphincter Augmentation Using Biological Material.

Nasra N Alam1, Sunil K Narang1, Ferdinand Köckerling2

  • 1Exeter Surgical Health Services Research Unit (HeSRU), Royal Devon and Exeter Hospital , Exeter , UK.

Frontiers in Surgery
|December 5, 2015
PubMed
Summary
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Biological materials show short-term benefits for anal sphincter repair and anal bulking procedures, improving quality of life and continence. Long-term efficacy requires further investigation for these anal incontinence treatments.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Biomaterials Science

Background:

  • Biological materials are increasingly explored for anal sphincter augmentation.
  • This review examines their use in overlapping sphincter repair (OSR) and anal bulking procedures.

Purpose of the Study:

  • To provide an overview of biological material applications in anal sphincter augmentation.
  • To assess the efficacy and outcomes of these procedures.

Main Methods:

  • Systematic literature search of PubMed using relevant keywords.
  • Identification and analysis of five studies involving biological materials in OSR or anal bulking.

Main Results:

  • Anal bulking with biological material in 122 patients showed short-term Quality of Life (QoL) improvements but no significant change in anorectal physiology.
Keywords:
anal bulkinganal encirclementanal sphincter repairbiological materialfecal incontinenceoverlapping sphincter repair

Related Experiment Videos

  • Sphincter encirclement with biological material in 23 patients improved QoL and reduced incontinence episodes significantly.
  • Short-term improvements in continence and QoL were observed for OSR and encirclement procedures.

    • Conclusions:

    • Sphincter encirclement with biological material offers short-term gains in continence and QoL compared to traditional repair.
    • Biological material as an anal bulking agent provides only short-term benefits.
    • Further long-term studies are needed to confirm sustained efficacy.