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Published on: May 19, 2022
Increased Peroxiredoxin 6 Expression Predicts Biochemical Recurrence in Prostate Cancer Patients After Radical
Sami Raatikainen1, Sirpa Aaaltomaa2, Vesa Kärjä3
1Department of Surgery, Kuopio University Hospital, Kuopio, Finland Department of Surgery, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland sami.raatikainen@kuh.fi.
Background/Aim:
Elevated levels of oxidative stress biomarkers have been shown to associate with more aggressive behavior in malignancies. The aim of the present study was to determine the relationship between the expression of peroxiredoxins (Prx) and sulfiredoxin (Srx) in localized prostate cancer (PC) with clinicopathological parameters and outcome after radical prostatectomy (RP).
Materials And Methods:
Samples of 240 RP patients were analyzed for Prx1, 2, 5 and 6 and Srx expression by immunohistochemistry and the results were correlated with clinicopathological data, biochemical recurrence-free survival (BFS), prostate cancer-specific survival (PCS) and overall survival (OS).
Results:
Augmented Prx2 and Prx6 expression was associated with several conventional prognostic factors. Increased Prx2 and Prx6 expression predicted for shortened BFS (p=0.027 and p=0.020) and worse OS (p=0.045 and p=0.033). In the multivariate analysis, Prx6 expression was an independent predictor of BFS (p=0.030).
Conclusion:
Elevated Prx6 expression associates with a worse prognosis after RP for clinically localized PC.
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