Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.0K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.6K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

745
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
745
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

582
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
582
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

955
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
955
Inflammation01:38

Inflammation

64.2K
Overview
64.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SIGNIFICANCE OF ADC MEASUREMENTS AS RADIOLOGICAL MRI MARKER IN DETECTION OF METASTATIC LYMPH NODE INVOLVEMENT IN PATIENTS WITH PROSTATE CANCER.

Experimental oncology·2022
Same author

Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model.

Experimental oncology·2021
Same author

[THE DYNAMICS OF THE INCIDENCE OF OPPORTUNISTIC INFECTIONS AND SOMATIC DISEASES HIV-INFECTED PATIENTS WHO RECEIVED INPATIENT TREATMENT IN 2006-2011].

Likars'ka sprava·2015
Same author

[Comparative assessment of nephroprotective properties of potassium and calcium channel modulators in experimental renal injury].

Eksperimental'naia i klinicheskaia farmakologiia·2014
Same author

[Chlorine dioxide as an agent for optimization of drinking water preparation].

Gigiena i sanitariia·2007
Same author

[Effect of sodium-rich diet and captopril on the functional state of kidney in rats with experimental hyperthyreosis].

Eksperimental'naia i klinicheskaia farmakologiia·2005

Related Experiment Video

Updated: Mar 29, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

[PREDICTORS OF ATHEROSCLEROSIS: NEW DEVELOPMENTS].

A I Gozhenko, S G Kotyuzhinskaya, L A Kovalevskaya

    Likars'Ka Sprava
    |December 8, 2015
    PubMed
    Summary

    This study explores heparin as an early atherosclerosis marker. Hyperheparinemia may indicate endothelial dysfunction, leading to lipid transport disorders and hyperlipidemia.

    Area of Science:

    • Cardiovascular Medicine
    • Biochemistry

    Context:

    • Atherosclerosis is a significant cardiovascular disease.
    • Early detection and monitoring of atherosclerosis are crucial for effective therapy.
    • Endothelial dysfunction is implicated in the early stages of atherosclerosis.

    Purpose:

    • To investigate the potential of heparin as an early diagnostic marker for atherosclerosis.
    • To understand the role of endothelial dysfunction in lipid metabolism disorders.

    Summary:

    • The article reviews known endothelial predictors for early atherosclerosis detection and therapy monitoring.
    • It analyzes heparin's potential as an early marker, linking hyperheparinemia to endothelial dysfunction.
    • This dysfunction inhibits lipoprotein lipase, causing resistant hyperlipidemia and dyslipidemia.

    Related Experiment Videos

    Last Updated: Mar 29, 2026

    A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
    05:51

    A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

    Published on: May 6, 2014

    13.8K

    Impact:

    • Provides insights into novel biomarkers for atherosclerosis.
    • May lead to improved diagnostic strategies for early-stage cardiovascular disease.
    • Highlights the connection between endothelial health and lipid metabolism.