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Epi-Drugs and Epi-miRs: Moving Beyond Current Cancer Therapies

Reza Salarinia, Amirhossein Sahebkar, Mostafa Peyvandi

  • 1Department of Medical Genetics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. r_salehi@med.mui.ac.ir.

Current Cancer Drug Targets
|December 8, 2015
PubMed

Insights

Epigenetic modifications like DNA methylation and histone changes influence cancer. Reversing these epigenetic changes offers a promising therapeutic strategy for cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic modifications, including DNA methylation and histone alterations, regulate gene expression and are implicated in cancer development.
  • These modifications are reversible, offering potential therapeutic targets for cancer treatment.

Purpose of the Study:

  • To explore the role of epigenetic modifications in cancer pathogenesis.
  • To discuss the therapeutic potential of targeting epigenetic mechanisms, including DNA methyltransferase, histone deacetylase, and Aurora B kinase.
  • To highlight the significance of microRNAs (miRNAs) as epigenetic regulators and potential biomarkers/therapeutic targets in cancer.

Main Methods:

  • Review of current literature on epigenetic modifications in cancer.
  • Analysis of the mechanisms underlying DNA methylation and histone modifications.
  • Investigation of the role of miRNAs in epigenetic gene regulation and cancer.

Main Results:

  • Epigenetic modifications are crucial in cancer development and progression.
  • Inhibition of key epigenetic enzymes can reverse gene silencing and impact cancer.
  • MicroRNAs play a significant role in epigenetic control and represent valuable diagnostic and therapeutic targets.

Conclusions:

  • Epigenetic modifications are key drivers in cancer and offer reversible therapeutic targets.
  • Targeting epigenetic machinery, including miRNAs, presents a promising avenue for novel cancer therapies.

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