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Related Concept Videos

Translation01:31

Translation

160.0K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Translation01:31

Translation

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Translation01:31

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Improving Translational Accuracy02:07

Improving Translational Accuracy

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Improving Translational Accuracy02:07

Improving Translational Accuracy

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Pulldown Assay Coupled with Co-Expression in Bacteria Cells as a Time-Efficient Tool for Testing Challenging Protein-Protein Interactions
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Russian translations for Cochrane.

E V Yudina, L E Ziganshina

    The International Journal of Risk & Safety in Medicine
    |December 8, 2015
    PubMed
    Summary

    Russian translations of Cochrane reviews enhance evidence-based medicine accessibility for Russian speakers. The project is highly valued, with users finding translations clear, relevant, and impactful for their health decisions.

    Area of Science:

    • Evidence-based medicine
    • Health information accessibility
    • Medical translation quality assessment

    Background:

    • Cochrane Collaboration is a global standard for credible medical evidence.
    • English-only access to Cochrane Reviews created a barrier for non-English speakers.
    • Initiation of translating Plain Language Summaries (PLS) into other languages in 2014.

    Purpose of the Study:

    • Assess the quality of Russian translations of Cochrane PLS.
    • Evaluate the potential impact of these translations on the Russian-speaking community.
    • Gather user feedback to improve the ongoing translation project.

    Main Methods:

    • Continuous online survey conducted via Google Docs.
    • Respondents recruited through Russian medical forums, Cochrane websites, and contributor databases.
    Keywords:
    Cochraneplain language summariesrussian translations

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  • Questionnaire covered relevance, impact, clarity, preferred style, and improvement suggestions.

    • Main Results:

    • Over 446 PLS translated into Russian by September 2015.
    • 94% of respondents found the project essential for Russia and Russian-speaking countries.
    • 87% reported potential impact on their individual practices/attitudes; 92% found translations clear.

    Conclusions:

    • The Russian PLS translation project received positive feedback regarding clarity, quality, and reader satisfaction.
    • The project is confirmed as important and relevant for a diverse Russian-speaking audience.
    • User feedback provides valuable insights for future improvements in translation quality and style adaptation.