Jove
Visualize
Contact Us

Related Concept Videos

Comparing Experimental Results: Student's t-Test01:09

Comparing Experimental Results: Student's t-Test

6.1K
The t-test is a statistical method used to compare the sample mean with a population mean or compare two means from two data sets. The test statistic is calculated from the standard deviation, mean, and number of measurements in the data set at a selected confidence interval and then compared to a table of critical values at this confidence level. If the test statistic is smaller than the critical value, the null hypothesis is accepted. In this case, we state that the difference between the...
6.1K
Inflammation01:38

Inflammation

62.3K
Overview
62.3K
Self-Efficacy01:29

Self-Efficacy

234
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
234
Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

279
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
279
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

572
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
572

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resource use during systematic review production varies widely: a scoping review: authors' reply.

Journal of clinical epidemiology·2021
Same author

Resource use during systematic review production varies widely: a scoping review.

Journal of clinical epidemiology·2021
Same author

POST-ANESTHETIC REHABILITATION PERIODS AND ANESTHESIA DOSAGE FOR LAPAROSCOPIC CHOLECYSTECTOMY: RELATIONSHIP TO THE TOTAL OXIDATIVE CAPACITY OF LIVER.

Eksperimental'naia i klinicheskaia farmakologiia·2018
Same author

[Efficacy of Management for Rational Use of Antibiotics in Surgical Departments at a Multi-Disciplinary Hospital: Results of a 7-year Pharmacoepidemiological Research].

Vestnik Rossiiskoi akademii meditsinskikh nauk·2018
Same author

[ANTIOXIDANT ACTIVITY OF XYMEDONE IN RATS WITH CHRONIC AUTOIMMUNE INFLAMMATION].

Eksperimental'naia i klinicheskaia farmakologiia·2016
Same author

Russian translations for Cochrane.

The International journal of risk & safety in medicine·2015
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 10, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
08:16

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

8.0K

[NEW APPROACH TO COMPARING NSAID EFFICACY BY LONG-TERM MONITORING OF EXPERIMENTAL INFLAMMATION MODELS.]

Hanh Cong Hong, V N Khaziakhmetova, L E Ziganshina

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |May 24, 2018
    PubMed
    Summary
    This summary is machine-generated.

    New methods for evaluating inflammatory burden revealed that common NSAIDs do not affect the total inflammatory burden in mouse and rat paw edema models. This highlights the need for novel approaches in anti-inflammatory drug discovery.

    More Related Videos

    Experimental Approaches to Tissue Engineering
    16:41

    Experimental Approaches to Tissue Engineering

    Published on: August 30, 2007

    6.8K
    Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
    08:17

    Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

    Published on: February 23, 2024

    5.6K

    Related Experiment Videos

    Last Updated: Feb 10, 2026

    An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
    08:16

    An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

    Published on: July 7, 2017

    8.0K
    Experimental Approaches to Tissue Engineering
    16:41

    Experimental Approaches to Tissue Engineering

    Published on: August 30, 2007

    6.8K
    Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
    08:17

    Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

    Published on: February 23, 2024

    5.6K

    Area of Science:

    • Pharmacology
    • Inflammation Research
    • Drug Discovery

    Background:

    • Carrageenan and formalin injections are common models for studying inflammatory edema.
    • Long-term observation reveals significant differences between carrageenan and formalin-induced inflammation.
    • Formalin causes irreversible damage, unlike carrageenan, and induces higher intensity edema.

    Purpose of the Study:

    • To introduce a novel method for assessing total inflammatory burden.
    • To evaluate the efficacy of conventional NSAIDs using this new method.
    • To guide future research in identifying effective anti-inflammatory agents.

    Main Methods:

    • Induction of inflammatory edema in mice and rats using carrageenan and formalin.
    • Long-term monitoring of inflammation intensity over time.
    • Calculation of the area under the inflammation intensity-time curve to quantify total inflammatory burden.
    • Administration of conventional NSAIDs (naproxen, diclofenac, indomethacin).

    Main Results:

    • Carrageenan and formalin models exhibit distinct long-term inflammatory profiles.
    • The proposed 'total inflammatory burden' metric quantifies inflammation comprehensively.
    • Conventional NSAIDs demonstrated no significant effect on the total inflammatory burden in either edema model.

    Conclusions:

    • The study introduces a valuable new metric for evaluating inflammatory processes.
    • Conventional NSAIDs are ineffective in mitigating the total inflammatory burden in these models.
    • Novel strategies and compounds are required for developing effective anti-inflammatory therapies.