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Pharmacokinetic interactions of penicillamine in rheumatoid arthritis
1Department of Internal Medicine, Danderyed Hospital, Sweden.
The Journal of Rheumatology
|April 1, 1989
Abstract:
The pharmacokinetic effect of the combined treatment of penicillamine with indomethacin and chloroquine was investigated in patients with rheumatoid arthritis. The mean plasma penicillamine concentration increased by 26% during indomethacin and 34% during chloroquine treatment. This new pharmacokinetic interaction may have important clinical implications.