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Published on: June 21, 2018
N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma
Berran Yucesoy1, Grace E Kissling, Victor J Johnson
1Division of Immunology, Allergy and Rheumatology (Drs Yucesoy, Lummus, and Bernstein), University of Cincinnati, Ohio; NIEHS/NIH (Dr Kissling), Research Triangle Park; BRT-Burleson Research Technologies (Dr Johnson), Morrisville, North Carolina; Hôpital du Sacré-Coeur de Montréal (Drs Gautrin and Cartier), Université de Montréal, Montreal, Quebec; Hôpital Laval (Dr Boulet), Université Laval, Sainte-Foy, Québec, Canada; Department of Allergy (Dr Sastre), Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES; Department of Allergy (Dr Quirce), Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; Department of Medicine and Dalla Lana School of Public Health (Dr Tarlo), University of Toronto, Ontario, Canada; Hospitals Vall D'Hebron (Drs Cruz and Munoz), Barcelona and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; and School of Public Health (Dr Luster), West Virginia University, Morgantown.
Objective:
To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA).
Methods:
The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5'-nuclease polymerase chain reaction assay.
Results:
The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P = 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genotype, NAT1 rs8190845*NAT2 rs13277605, were significantly associated with DA risk (P = 0.022, P = 0.036, respectively).
Conclusions:
These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.
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