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Updated: Mar 29, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Burkholderia cepacia complex: clinical course in cystic fibrosis patients
Tania Wrobel Folescu1, Claudia Henrique da Costa2, Renata Wrobel Folescu Cohen3
1Department of Pediatric Pulmonology, Instituto Fernandes Figueira (Fundação Oswaldo Cruz, Ministério da Saúde), Av. Rui Barbosa, 716, 2nd floor, Flamengo, Zip Code: 22250-020, Rio de Janeiro, RJ, Brazil. taniafolescu@hotmail.com.
Background:
Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.
Methods:
CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.
Results:
Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.
Conclusions:
Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.
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