Related Experiment Video
Updated: Mar 29, 2026
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
14.7K
Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model
Alexandra S Gersing1, Andrea M Faymonville2, Benedikt J Schwaiger1
1Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Journal of Neuroscience Methods
|December 10, 2015
Summary
Quantitative T2* imaging reveals rapid changes in ischemic tissue, reflecting deoxyhemoglobin levels. This non-invasive method shows potential for acute stroke oxygenation assessment without contrast agents.
Area of Science:
- Neuroimaging
- Biophysics
Background:
- Oxyhemoglobin-sensitive T2* sequences indirectly reflect oxygen extraction changes.
- Understanding T2* dynamics in ischemic tissue is crucial for assessing metabolic impairment.
Purpose of the Study:
- To investigate the temporo-spatial dynamics of T2* changes in ischemic brain tissue.
- To evaluate quantitative T2* imaging as a non-invasive biomarker for metabolic changes in stroke.
Main Methods:
- Middle cerebral artery occlusion (MCAO) induced in a mouse model.
- Serial quantitative T2* and diffusion-weighted imaging acquired post-MCAO and post-recanalization.
- T2* maps co-registered with histology for precise infarct core and surrounding tissue analysis.
Main Results:
- Significant T2* decrease (-10.8%) observed in the infarct core within 3.5 minutes of MCAO.
- T2* values in surrounding tissue showed less decrease and increased post-recanalization.
- Volume of T2* abnormality correlated significantly with infarct core volume.
Conclusions:
- This study is the first to use non-invasive quantitative T2* to assess deoxyhemoglobin in ischemic tissue.
- Quantitative T2* imaging is a feasible tool for evaluating oxygenation changes in acute stroke.
- This method offers a contrast agent-free approach for stroke imaging.
