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Updated: Mar 29, 2026

Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
Translational strategies in aging and age-related disease
Mary Armanios1, Rafael de Cabo2, Joan Mannick3
1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract:
Aging is a risk factor for several of the world's most prevalent diseases, including neurodegenerative disorders, cancer, cardiovascular disease and metabolic disease. Although our understanding of the molecular pathways that contribute to the aging process and age-related disease is progressing through the use of model organisms, how to apply this knowledge in the clinic is less clear. In September, Nature Medicine, in collaboration with the Volkswagen Foundation, hosted a conference at the beautiful Herrenhausen Palace in Hannover, Germany with the goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in disease. Here, several of the speakers at that conference answer questions posed by Nature Medicine.
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