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One-carbon metabolism and epigenetics: understanding the specificity

Samantha J Mentch1, Jason W Locasale1,2,3,4

  • 1Field of Biochemistry, Molecular, and Cell Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York.

Annals of the New York Academy of Sciences
|December 10, 2015
PubMed
Summary

One-carbon metabolism fuels histone methylation via S-adenosylmethionine (SAM), linking nutrient status to gene regulation. This study explores histone methyltransferases (HMTs), SAM production, and their specific metabolic connections.

Keywords:
epigeneticshistone methylationhistone methyltransferaseone-carbon metabolism

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