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Disseminated Emmonsia pasteuriana infection in India: a case report and a review

Rupali Malik1, Malini R Capoor2, Ilavarasi Vanidassane1

  • 1Department of Medicine, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, New Delhi, India.

Mycoses
|December 10, 2015
PubMed

Insights

This study details the first reported case of disseminated Emmonsia pasteuriana infection in an Indian AIDS patient. Early diagnosis and treatment with amphotericin B and itraconazole led to a positive patient response.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunocompromised Hosts

Background:

  • Disseminated fungal infections pose a significant threat to individuals with advanced HIV/AIDS.
  • Emmonsia pasteuriana is an emerging fungal pathogen with limited documented human infections.
  • Identifying novel fungal infections in immunocompromised populations is crucial for public health.

Observation:

  • A patient with Acquired Immunodeficiency Syndrome (AIDS) in India presented with prolonged constitutional symptoms and mucocutaneous lesions.
  • Clinical presentation included weight loss, dyspnea, chest pain, and multiple skin lesions.
  • Microscopic examination and fungal culture of biopsy and aspirate samples revealed Emmonsia pasteuriana.

Findings:

  • The diagnosis of disseminated emmonsiosis was confirmed through molecular techniques, including sequencing of rDNA ITS, beta tubulin, actin, and intein PRP8.
  • This marks the first documented case of disseminated Emmonsia pasteuriana infection in India.
  • The patient demonstrated clinical improvement following treatment with amphotericin B and itraconazole.

Implications:

  • This case highlights the importance of considering rare fungal pathogens in the differential diagnosis of opportunistic infections in AIDS patients.
  • Early and accurate diagnosis, aided by molecular methods, is critical for effective management.
  • The successful treatment response suggests potential therapeutic strategies for disseminated emmonsiosis.
Keywords:
EmmonsiaHIVdisseminated infection

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