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Methods in renal research: kidney transplantation in the rat
Xavier Tillou1,2, Brian O Howden3, John Kanellis1
1Department of Nephrology, Monash Health and Department of Medicine, Southern Clinical School, Monash University, Monash Medical Centre, Melbourne, Victoria, Australia.
Nephrology (Carlton, Vic.)
|December 10, 2015
Abstract:
Kidney transplantation in small animals has been crucial in the development of anti-rejection therapies. While there is no substitute for a skilled microsurgeon, there are many aspects of the transplant procedure that can be modified to optimize the reproducibility and utility of the technique. This article provides a detailed description, including video recording, of orthotopic kidney transplantation in the rat. The key variables in the technique are also discussed.